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Objective: To retrospectively analyze the clinical data of 52 patients with coronavirus disease-2019 COVID-19 and explore the clinical efficacy of modified Sanxiaoyin on mild/moderate COVID-19 patients. Method(s): The propensity score matching method was used to collect the clinical data of mild or moderate COVID-19 patients enrolled in the designated hospital of the Second Hospital of Jingzhou from December 2019 to May 2020. A total of 26 eligible patients who were treated with modified Sanxiaoyin were included in the observation group,and the 26 patients treated with conventional method were the regarded as the control. The disappearance of clinical symptoms,disappearance time of main symptoms,efficacy on traditional Chinese medicineTCMsymptoms,hospitalization duration,laboratory test indicators,and CT imaging changes in the two groups were compared. Result(s): The general data in the two groups were insignificantly different and thus they were comparable. After 7 days of treatment,the disappearance rate of fever,cough, fatigue,dry throat,anorexia,poor mental state,and poor sleep quality in the observation group was higher than that in the control groupP<0.05,and the difference in the disappearance rate of expectoration and chest distress was insignificant. For the cases with the disappearance of symptoms,the main symptomsfever, cough,fatigue,dry throat,anorexia,chest distressdisappeared earlier in the observation group than in the control groupP<0.01. After 7 days of treatment,the scores of the TCM symptom scale of both groups decreasedP<0.01,and the decrease of the observation group was larger that of the control groupP<0.01. All patients in the two groups were cured and discharged. The average hospitalization duration in the observation group12.79+/-2.68dwas shorter than that in the control group15.27+/-3.11dP<0.01. The effective rate in the observation group92.31%,24/26was higher than that in the control group76.92%,20/26. After 7 days of treatment,the lymphocyteLYMcount increasedP<0.05,and white blood cellWBCcount and neutrophilNEUTcount decreased insignificantly in the two groups. Moreover,levels of C-reactive protein CRP,erythrocyte sedimentation rateESR,and procalcitoninPCTreduced in the two groups after treatmentP<0.01and the reduction in the observation group was larger than that in the control group P<0.01. Through 7 days of treatment,the total effective rate on pulmonary shadow in the observation group 90.00%,18/20was higher than that in the control group77.27%,17/22P>0.05and the improvement of lung shadow in the observation group was better than that in the control groupP<0.01. Conclusion(s):Modified Sanxiaoyin can significantly alleviate fever,cough,fatigue,anorexia,chest distress,poor sleep quality,and other symptoms of patients with mild or moderate COVID-19,improve biochemical indicators,and promote the recovery of lung function. This paper provides clinical evidence for the application of modified Sanxiaoyin in the treatment of mild or moderate COVID-19.Copyright © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.
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With the normalization of the COVID-19 pandemic prevention and control, there is an urgent need to develop a healthy urban public space. However, because of the fast urbanization process with a series of problems, such as PM2.5 air pollution, the Urban Heat Island, and the relatively high frequency of static winds under the influence of its topography, the ventilation problem in the public spaces of Chengdu is of great importance. Along these lines, in this work, the history of theoretical research on urban ventilation is summarized and reviewed first to evaluate the urban wind environment. Second, so far, qualitative methods are mainly adopted for the evaluation methods of microclimate adaptation. However, the practical application has achieved few results. Meanwhile, there is still a lack of comprehensive and unified research on the multi-element of human microclimate comfort in public space. For this reason, the urban ventilation assessment system was established in this work according to the physical, physiological, and psychological aspects, with 9 indices selected and ranked. Then, an optimization strategy for rebuilding the urban public space was proposed for improving the wind environment microclimate adaption on three levels: macro city-regional level, meso block linear space, and micro space node. By taking Eastern Banlieue Memory Industrial Park as an example, the statistical data were systematically investigated on the spot from the results of 249 wind environment questionnaires, and 30 Delphi expert consultation questionnaires. Combined with the Computational Fluid Dynamics (CFD) simulation, the results reveal that most public spaces in the study area were below 0.6 m/s in more than 80% of the public space, and wind-based environmental problems obviously exist without any ventilation improvement measures. Combined with the background of the carbon peak era, the ventilation environment of the urban public space is not conducive to using active ventilation equipment. The solution of a complete set of regional intelligent ventilation systems was thoroughly discussed here, while some innovative sustainable systematic solutions and urban ventilation furniture combined with a geothermal heat pump and cloud data platform were formulated.
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Based on the online and membrane sampling data of Yuncheng from January 1st to February 12th, 2020, the formation mechanism of haze under the dual influence of Spring Festival and COVID-19 (Corona Virus Disease) was analyzed. Atmospheric capacity, chemical composition, secondary transformation, source apportionment, backward trajectory, pollution space and enterprise distribution were studied. Low wind speed, high humidity and small atmospheric capacity inhibited the diffusion of air pollutants. Four severe pollution processes occurred during the period, and the pollution degree was the highest around the Spring Festival. In light, medium and heavy pollution periods, the proportion of SNA (SO 4 2 ???, NO 3 ??? and NH 4 + ) was 59.6%, 56.0% and 54.9%, respectively, which was the largest components of PM 2.5 ;the [NO 3 ???]/[SO 4 2 ???] ratio was 2.1, 1.5 and 1.7, respectively, indicating that coal source had a great influence;the changes of NOR (nitrogen oxidation ratio, 0.44, 0.45, 0.61) and SOR (sulphur oxidation ratio, 0.40, 0.49, 0.65) indicated the accumulation of secondary aerosols with increasing pollution. The coal combustion, motor vehicle, secondary inorganic sources and industrial sources contributed 36.8%, 26.59%, 11.84% and 8.02% to PM 2.5 masses, respectively. Backward trajectory showed that the influence from the east was greater during the Spring Festival, and the pollutants from the eastern air mass were higher, which would aggravate the pollution. Meteorological and Spring Festival had a great impact on heavy pollution weather. Although some work could not operate due to the impact of the COVID-19 epidemic, the emission of pollutants did not reduce much. ?? 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
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［］ Objective： To retrospectively analyze the clinical data of 52 patients with coronavirus disease-2019 （COVID-19） and explore the clinical efficacy of modified Sanxiaoyin on mild/moderate COVID-19 patients. Method： The propensity score matching method was used to collect the clinical data of mild or moderate COVID-19 patients enrolled in the designated hospital of the Second Hospital of Jingzhou from December 2019 to May 2020. A total of 26 eligible patients who were treated with modified Sanxiaoyin were included in the observation group，and the 26 patients treated with conventional method were the regarded as the control. The disappearance of clinical symptoms，disappearance time of main symptoms，efficacy on traditional Chinese medicine（TCM）symptoms，hospitalization duration，laboratory test indicators，and CT imaging changes in the two groups were compared. Result： The general data in the two groups were insignificantly different and thus they were comparable. After 7 days of treatment，the disappearance rate of fever，cough， fatigue，dry throat，anorexia，poor mental state，and poor sleep quality in the observation group was higher than that in the control group（P<0.05），and the difference in the disappearance rate of expectoration and chest distress was insignificant. For the cases with the disappearance of symptoms，the main symptoms（fever， cough，fatigue，dry throat，anorexia，chest distress）disappeared earlier in the observation group than in the control group（P<0.01）. After 7 days of treatment，the scores of the TCM symptom scale of both groups decreased（P<0.01），and the decrease of the observation group was larger that of the control group（P<0.01）. All patients in the two groups were cured and discharged. The average hospitalization duration in the observation group［（12.79±2.68）d］was shorter than that in the control group［（15.27±3.11）d］（P<0.01）. The effective rate in the observation group（92.31%，24/26）was higher than that in the control group（76.92%，20/26）. After 7 days of treatment，the lymphocyte（LYM）count increased（P<0.05），and white blood cell（WBC）count and neutrophil（NEUT）count decreased insignificantly in the two groups. Moreover，levels of C-reactive protein （CRP），erythrocyte sedimentation rate（ESR），and procalcitonin（PCT）reduced in the two groups after treatment（P<0.01）and the reduction in the observation group was larger than that in the control group （P<0.01）. Through 7 days of treatment，the total effective rate on pulmonary shadow in the observation group （90.00%，18/20）was higher than that in the control group（77.27%，17/22）（P>0.05）and the improvement of lung shadow in the observation group was better than that in the control group（P<0.01）. Conclusion：Modified Sanxiaoyin can significantly alleviate fever，cough，fatigue，anorexia，chest distress，poor sleep quality，and other symptoms of patients with mild or moderate COVID-19，improve biochemical indicators，and promote the recovery of lung function. This paper provides clinical evidence for the application of modified Sanxiaoyin in the treatment of mild or moderate COVID-19. © 2022, China Academy of Chinese Medical Sciences Institute of Chinese Materia Medica. All rights reserved.
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The demand for biophotonics technologies has rapidly increased over the years and supply of professionals capable of working in multi- and inter-disciplinary topics associated with tissue optics and translating optical technologies to the clinic are still scarce. Despite the number of programs to created to increase the number of high-quality biophotonics professionals, most of these programs are focused on post-graduate audiences and involve in-person activities. Particularly on the education side, online teaching and learning (OTL) have exponentially grown over the years as universities adopted online courses. During the COVID-19 pandemic, social distancing restrictions required courses to be offered fully online. Educators have adopted combinations of resources including online apps, simulations, virtual labs, and massive open online courses (MOOCs) to complement recorded or video-conferenced classes. However, most of these resources were not designed to be integrated into virtual courses, compromising the quality of instruction/education especially in events relying on in-person activities to convey information quicker than online activities. These events include short-term courses and outreach events, where fostering students' engagement and interest with fully online activities can be challenging. The quality of instruction is further compromised when events involve multidisciplinary/interdisciplinary OTL, which includes biophotonics and biomedical optics courses. To overcome the aforementioned challenges, we have developed and tested a variety of activities and resources for a short-term virtual biophotonics workshop (BW) including webinars, at-home experiments, and computer simulations. Our BW targeted undergraduate students and secondary-school teachers with diverse backgrounds and offered activities to meet needs of learners with diverse backgrounds, learning styles and education levels. Resources provided self-paced learning over the duration of the workshop. Our participants' feedback for 2020 and 2021 BWs showed >78.6% of participating respondents considered every activity of the BW important for their learning process. Also, every BW activity received >69.2% "Very good"and ""Good"responses for overall learning, >91.7% for quality of teaching, >90% for quality of subject matter. Similarly, >75% of participants were "Very interested"or "Interested"in every activity. © COPYRIGHT SPIE.
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Background : Patients with hemophilia require regular assessments and physical examinations. The COVID-19 pandemic has resulted in the rapid adoption of telemedicine to enable virtual consultations and reduce hospital visits. However, the process of virtual consultations is new to many hemophilia clinics. A better understanding of best practices in telemedicine is important to ensure optimal quality of care for patients with hemophilia. Aims : To summarize the current literature on the use of direct-toconsumer telemedicine for patients with hemophilia and to describe the effectiveness and potential limitations of the technology and methods used. Methods : A comprehensive search was conducted in MEDLINE and EMBASE databases using the terms “hemophilia” AND “telemedicine” and their concept synonyms. There were no time or language restrictions. Title, abstracts, and full texts were screened. Included articles involved telemedicine interventions to facilitate clinical services directly between patients and providers without the use of third-party personnel. The primary outcome was the satisfaction of providers and patients. Secondary outcomes included economic considerations and clinical outcomes. Data were extracted based on study-specific, patient-specific, intervention-specific, and outcome-specific data. Results : Of the 925 articles screened, 6 articles were identified and summarized (Figure 1). Three articles described telemedicine within the context of COVID-19. Technologies used included telephone calls, videoconferencing, text messaging, and email. All studies involved a multidisciplinary team. Telemedicine in hemophilia care was found to positively impact the patient experience. Providers were satisfied with telemedicine. Telemedicine was economically beneficial and positively impacted patient outcomes. However, none of the articles reported on how telemedicine was specifically used to perform assessments during the virtual consultation process. Conclusions : The positive reception of telemedicine by patients and providers combined with the limited information available on methods of virtual assessments necessitates the development of a standard telemedicine guideline that can help providers learn how to best incorporate telemedicine to improve quality of care.
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We propose a novel approach that integrates machine learning into compartmental disease modeling (e.g., SEIR) to predict the progression of COVID-19. Our model is explainable by design as it explicitly shows how different compartments evolve and it uses interpretable encoders to incorporate covariates and improve performance. Explainability is valuable to ensure that the model’s forecasts are credible to epidemiologists and to instill confidence in end-users such as policy makers and healthcare institutions. Our model can be applied at different geographic resolutions, and we demonstrate it for states and counties in the United States. We show that our model provides more accurate forecasts compared to the alternatives, and that it provides qualitatively meaningful explanatory insights. © 2020 Neural information processing systems foundation. All rights reserved.